Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective

Table 2

Antidengue activities of natural compounds.

Botanical name	Plants part	Isolated compounds	Model	Results	References
Garcinia mangostana	Fruits	α-Mangostin	DENV infection in human peripheral blood mononuclear cells (PBMC) in vitro	↓ virus replication, ↓ TNF-α, ↓ IFN-γ, ↓ IL-6, ↓ MIP-1β, ↓ IP-10	[196, 197]
Anacolosa pervilleana	Leaves	Octadeca-9,11,13-triynoic acid	DENV NS5 RNA-dependent RNA polymerase (RdRp) assay in vitro		[198]
Streptomyces aureofaciens	Fermentation	Narasin	DENV2-infected hepatocytes Huh-7 cells in vitro	↓ viral protein synthesis	[199]
Glycyrrhiza glabra	Root	Glycyrrhizin	DENV serotypes1-3 in vitro	, 174.2, 632.7 μg/mL	[200]
		Glycyrrhizic acid	DENV2 infected Vero E6 cells in vitro		[201]
Squalus acanthias	Liver	Squalamine	Human endothelial cells HMEC-1 in vitro	↓ viral infection	[202]
Zastera marina. Rees	Marine eelgrass	Zoasteric acid	DENV serotypes (1–4) in vitro	, 46, 14, 47 μmol/L	[137]
Quercus lusitanica	Galls	Methyl gallate	DENV-2 infected C6/36 cells in vitro	↓ DENV-2 NS2B/3 protease; ↓NS1 protein	[203]
Flacourtia ramontchi	Stem bark	Flacourtosides A, E	DENV NS5 polymerase RdRp in vitro		[204]
Gymnochrinus richeri	Stalked fossil crinoïd	Gymnochrome B	DENV-2, DENV-4 infected PS cells in vitro		[205]
Gymnochrinus richeri	Living fossil crinoid	Gymnochrome D, isogymnochrome D	DENV-1 infected PS cells in vitro	Reduction of foci was smaller than 1 μg/mL	[206]
Arrabidaea pulchra	Leaves	Verbascoside, caffeoylcalleryanin, ursolic acid	DENV-2 infected Vero cells in vitro	, 2.8, 3.4 μg/mL	[207]
Trigonostemon cherrieri	Bark and wood	Trigocherrin A, trigocherriolides A and B	DENV NS5 polymerase RdRp in vitro	, 3.1, 16.0 μmol/L	[208]
Micromonospora rhodorangea	Whole part	Geneticin	DENV-2 infected BHK cells in vitro		[209]
Castanospermum australe	Seeds	Castanospermine	DENV-2 infection of Huh-7 and BHK-21 cells 10^5 PFU of mouse-adapted DENV-2 in vitro/in vivo	↓ mortality in a mouse model; , 50, and 250 mg/kg	[210]
Coptis chinensis Franch	Rhizomes	Palmatine	DENV-2 infected Vero cells in vitro		[211]
Psychotria Ipecacuanha	Roots	Emetine hydrochloride	DENV-2 infected Huh-7, BHK-21 in vitro		[212]
Distictella elongate (Vahl) Urb	Leaves and fruits	Petcolinarin and acacetin-7-O-Rutinoside	DENV-2 infected Vero, LLCMK2 cells in vitro		[213, 214]
Scutellaria baicalensis	Roots	Baicalein	DENV-2 infected Vero cells in vitro		[180, 215]
Cryptocarya chartacea	Barks	Chartaceones C-F	Dengue virus NS5 RdRp inhibition in vitro		[216, 217]
Boesenbergia rotunda (L.)	Rhizomes	Panduratin A 4-hydroxypanduratin B	DENV-2 NS2B/NS3 protease in vitro		[123]
Tephrosia s.p.	Aerial parts	Glabranine 7-O-methyl-glabranine	DENV-2 serotype in vitro	70% inhibition	[134]
Mimosa scabrella	Seeds	Mannose/galactose (1 : 1)	DENV-1 (Hawaii strain) virus in vitro	↓ virus titer	[114, 131]
Leucaena leucocephala		Mannose/galactose (1 : 4)		↓ virus titer	[114, 131]
Gymnogongrus torulosus	Red seaweed	DL-galactan hybrids	DENV-2 serotype infected Vero cells in vitro		[128]
G. griffithsiae and Cryptonemia crenulata		Sulfated G3d and C2S-3 polysaccharides			[125]
Cladosiphon okamuranus	Brown seaweeds	Fucoidan	DENV-2 infected BHK-21 cells in vitro		[78, 218]
Nephelium lappaceum L.	Whole plant	Geraniin	DENV-2 E domain III (rE-DIII) protein in vitro		[219, 220]
Scutellaria baicalensis	Radices	Baicalin	DENV-2 (NGC strain) infected Vero cells in vitro		[221, 222]
Camellia sinensis	Dried leaves	Epigallocatechin gallate	Dengue virus (serotypes 1–4) infected Vero cells in vitro		[223]
Zoanthus spp.	Animal materials	Zoanthone A	DENV-2 NS5 polymerase in vitro		[224]
Mammea americana	Seeds	Coumarin A; Coumarin B	DENV-2/NG strain in vitro		[225]
Tabernaemontana cymosa	Seeds	Lupeol acetate; Voacangine			[225]
Angelica keiskei	Roots	Brefeldin A	DENV serotypes (1–4) in vitro	(DENV-2)	[226]
Uncaria rhynchophylla	Leaves	Hirsutine	DENV-1 infected A549 cells in vitro		[227]
Viola yedoensis Makino	Aerial parts	Luteolin	DENV infected HEK-293 T, A549, and BHK-21 cells in vitro		[228]
Persea americana	Fruits	(2 R,4 R)-1,2,4-Trihydroxyheptadec-16-yne	DENV serotypes (1–4) in vitro		[229]
Nephelium lappaceum	Rind	Geraniin	DENV-2 RNA synthesis in Vero cells in vitro		[195]
Palythoa mutuki	Formosan zoanthid	Peridinin	DENV NS2B/NS3 protease in vitro		[230]
Ganoderma lucidum	Fruiting bodies	Ganodermanotriol			[231]
Faramea bahiensis	Leaves	5-Hydroxy-4-methoxy-flavanone-7-O-ß-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside	DENV-2 in HepG2 cells in vitro	↓ viral replication; ↓ infected cell number	[232]
Rhodiola rosea	Roots	Salidroside	DENV serotype-2 infection in vitro	↓ DENV envelope protein; ↑ RNA helicases	[233]
Swietenia macrophylla	Seeds	Swielimonoid B			[234]