BioMed Research International

Research Article

Exploring the Pleiotropic Genes and Therapeutic Targets Associated with Heart Failure and Chronic Kidney Disease by Integrating metaCCA and SGLT2 Inhibitors’ Target Prediction

Table 1

Potential therapeutic genes identified by metaCCA and SGLT2 target prediction.
GenemetaCCA valueGene type—HFGene type—CKD
SLC5A1ConfirmedConfirmed
EP300ConfirmedConfirmed
GRIK1NovelNovel
CYP2C9ConfirmedConfirmed
IARSNovelNovel
ADORA3ConfirmedConfirmed
DPP4ConfirmedConfirmed
FDFT1NovelNovel
CHEK1ConfirmedNovel
MANBANovelConfirmed
HSP90AA1ConfirmedNovel
METConfirmedNovel
CASP7ConfirmedNovel
GAKNovelNovel
DNMT1ConfirmedConfirmed
SCN9AConfirmedNovel
JAK2ConfirmedConfirmed
IKBKBNovelConfirmed
SLCO1B3NovelConfirmed
PFKFB3ConfirmedNovel
GLB1NovelNovel
Confirmed: this gene was previously reported to be associated with disease. Novel: this gene had never been reported to be associated with HF or CKD.