Comparable Effects of Strontium Ranelate and Alendronate Treatment on Fracture Reduction in a Mouse Model of Osteogenesis Imperfecta

Figure 1

Evaluation of the animal growth for the duration of the study. (a) Growth curves of the bodyweight for different groups of mice. Veh-treated oim/oim mice remained significantly smaller than their wt/wt mice at both 3 and 14 weeks. SrR or Aln treatment did not change the body weight of either genotype. (b) Femoral length of the animals from different groups at 14 weeks of age. The oim/Veh mice had shorter femoral length than wt/Veh mice. SrR and Aln had no effects on femoral length. Values were expressed as ; for oim/Veh group (missing data due to death), for oim/SrR and oim/Aln group (missing data due to death), for all the wt groups. wt/Veh vs. oim/Veh.

(a)

(b)