Comparable Effects of Strontium Ranelate and Alendronate Treatment on Fracture Reduction in a Mouse Model of Osteogenesis Imperfecta

<div>Effects of different treatments on fracture reduction in oim/oim mice. Representative radiographs of (a) Veh-treated, (b) SrR-treated, and (c) Aln-treated oim/oim mice. Red arrow: fractures at different locations. (d) Representative radiograph of Veh-treated wt/wt mice. (e) Statistical analysis of fractures sustained at 14 weeks of age by oim/oim mice after 11 weeks of treatment with Veh, SrR, and Aln. Compared with Veh treatment, the number of fractures was significantly reduced with SrR or Aln treatment. 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BioMed Research International

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Figure 2

Figure 2: Comparable Effects of Strontium Ranelate and Alendronate Treatment on Fracture Reduction in a Mouse Model of Osteogenesis Imperfecta 