Comparable Effects of Strontium Ranelate and Alendronate Treatment on Fracture Reduction in a Mouse Model of Osteogenesis Imperfecta

Figure 5

Effects of different treatments on femora cortical bone mass. (a) Representative micro-CT images of cortical regions in femora reveal positive effects on bone cortices with SrR or Aln treatment. (b) SrR or Aln treatment had no alteration in cortical BMD for both genotypes. (c, e) Cort.Th, and Cort.CSA were significantly increased with SrR or Aln in both wt/wt and oim/oim mice. (d, f) No significant changes were observed in total area and periosteal perimeter after SrR or Aln treatment for both genotypes. (g) Marrow area was significantly decreased after SrR or Aln treatment in wt/wt mice, while only a small decreasing trend was observed in oim/oim mice. Values were expressed as ; animals per group for oim/oim and wt/wt groups (missing data due to deformity or fractures). , compared with the same genotype vehicle. , wt/Veh vs. oim/Veh. , SrR vs. Aln treatment for the same genotype. , wt/Veh vs. oim/SrR group or oim/Aln group.

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