Research Article

Comparable Effects of Strontium Ranelate and Alendronate Treatment on Fracture Reduction in a Mouse Model of Osteogenesis Imperfecta

Table 1

Biomechanical properties of femoral cortical bone after 11 weeks of treatment ().

Parametersoim/Veh ()oim/SrR ()oim/Aln ()wt/Veh ()wt/SrR ()wt/Aln ()

Moment of inertia (mm4)
Maximum load (N)
Stiffness (N/mm)
Energy to failure (mJ)
Young’s modulus (MPa)
Total strain
Ultimate stress (MPa)
Yield force (N)
Yield displacement (mm)
Postyield displacement (mm)
Total displacement (mm)

Notes. Veh, vehicle; SrR, strontium ranelate; Aln, alendronate. , significantly different compared with same genotype vehicle. , significantly different between wt/Veh vs. oim/Veh. , significantly different between SrR vs. Aln treatment for the same genotype. , significantly different between wt/Veh vs. oim/SrR group or oim/Aln group.