Design and Optimization of Cationic Nanocapsules for Topical Delivery of Tretinoin: Application of the Box-Behnken Design, <i>In Vitro</i> Evaluation, and <i>Ex Vivo</i> Skin Deposition Study

<div>Skin retention (<i>μ</i>g/cm<sup>2</sup>) of hydrogel containing tretinoin-loaded lipid-core nanocapsules (HG-TTN-LCNC), tretinoin solution (HG-TTN), and commercial gel (HG-C) in the abdominal rat skin. 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BioMed Research International

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Figure 6

Figure 6: Design and Optimization of Cationic Nanocapsules for Topical Delivery of Tretinoin: Application of the Box-Behnken Design, <i>In Vitro</i> Evaluation, and <i>Ex Vivo</i> Skin Deposition Study 

Figure 6 | Design and Optimization of Cationic Nanocapsules for Topical Delivery of Tretinoin: Application of the Box-Behnken Design, In Vitro Evaluation, and Ex Vivo Skin Deposition Study 