Design and Optimization of Cationic Nanocapsules for Topical Delivery of Tretinoin: Application of the Box-Behnken Design, In Vitro Evaluation, and Ex Vivo Skin Deposition Study

Table 5

The suggested formulations by Design Expert® 14.0.0 software.

Solution number efficiency	Polymer amount (mg)	Oil amount (ml)	Drug amount (mg)	Size (nm)	Entrapment	Desirability
1	110.47	0.2	17.39	127.25	92.3736	0.898
2	113.86	0.2	17.80	127.25	92.3182	0.897
3	103.97	0.2	17.30	127.25	92.3027	0.897
4	105.54	0.2	18.92	127.25	91.8058	0.892
5	99.81	0.2	15.61	127.25	91.4696	0.888
6	84.98	0.2	16.10	127.25	90.9541	0.883
7	87.33	0.2	20.00	127.25	89.9737	0.872
8	74.11	0.2	14.97	127.25	88.9248	0.861
9	65.45	0.2	18.52	127.25	88.8467	0.860