Design and Optimization of Cationic Nanocapsules for Topical Delivery of Tretinoin: Application of the Box-Behnken Design, In Vitro Evaluation, and Ex Vivo Skin Deposition Study

Table 6

Predicted and observed values for the optimized encapsulated TTN ().

(a)

Factor	Optimized level
: polymer amount (mg)	110.47
: oil amount (ml)	0.2
: drug amount (mg)	17.39

(b)

Response (%)^a	Expected	Observed error	Prediction
: EE (%)	92.37		-11.02
: particle size (nm)	127.25		-9.40

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