Research Article
Melatonin Suppresses Apoptosis of Nucleus Pulposus Cells through Inhibiting Autophagy via the PI3K/Akt Pathway in a High-Glucose Culture
Figure 6
Inhibition of the PI3K/Akt pathway attenuated nucleus pulposus (NP) cell apoptosis in a high-glucose culture. (a–d) Results of cell apoptosis ratio, caspase-3/caspase-9 activity, mRNA expression of apoptosis-related molecules, and mRNA expression of autophagy-related molecules, respectively. Data are exhibited as , . A statistical difference (). Con: control; HG: high glucose; HG+MLT(1.0): high gl ucose+1.0 mM melatonin.
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