BioMed Research International / 2021 / Article / Tab 1 / Review Article
Application of Primary/Secondary Circulating Tumor Cells for the Prediction of Biochemical Recurrence in Nonmetastatic Prostate Cancer Patients following Radical Prostatectomy or Radiotherapy: A Meta-Analysis Table 1 Summary of eligible studies.
Study Design Country Treatment procedures CTC detection methods Median (mean) initial PSA level (range) (ng/ml) Median follow-up (range) (months) Samples were collected prior to treatment Samples were collected after treatment NOS score (max: 9), for non-RCT Number of BF/CTC+ patients Number of BF/CTC− patients Number of BF/CTC+ patients Number of BF/CTC− patients Zapatero et al., 2020 [34 ] Prospective cohort study Spain RT CSS 12.6 (3.2–68.7) 55 (10–40) 0/8 1/54 0/11 1/48 6 Thalgott et al., 2015 [33 ] Prospective cohort study Germany RP CSS 23 (40.7) (5.7–260.0) 44.3 (25–52) 3/6 4/9 3/4 4/11 6 Murray et al., 2016 [29 ] Prospective cohort study Chile RP Density gradient centrifugation+immunocytochemistry 5.89 60 98/224 5/61 — — 7 Murray et al., 2016 [17 ] Prospective cohort study Chile RP Density gradient centrifugation+immunocytochemistry 5.7 60 93/211 4/56 — — 7 Murray et al., 2018 [16 ] Prospective cohort study Chile RP Density gradient centrifugation+immunocytochemistry 5.52 (36–60) — — 109/127 22/194 7 Murray et al., 2020 [30 ] Prospective cohort study Chile RT Density gradient centrifugation+immunocytochemistry 6.3 96.36 (9.6–183.6) — — 80/112 46/197 8 Meyer et al., 2016 [24 ] Prospective cohort study Germany RP CSS 6.6 (0.04–87) 44.3 (48/36–60) 5/17 43/135 — — 7 Murray et al., 2013 [31 ] Prospective cohort study Chile RP Density gradient centrifugation+immunocytochemistry NR NR — — 25/38 5/56 6 Pal et al., 2015 [32 ] Prospective cohort study America RP CSS NR 17 (3.6–29.8) 6/16 8/16 11/15 11/17 7 Salami et al., 2019 [25 ] Prospective cohort study America RP or RT RBC lysis+immunocytochemistry RP: 6.7 (1.8, 66.0) RT: 11.9 (1.2, 74.1) 14.2 (0.5–43.7) RP: 13/19 RT: 0/14 RP: 2/7 RT: 1/5 — — 7 Helo et al., 2009 [28 ] Prospective cohort study America RP RT-PCR NR NR 0/6 6/81 0/6 4/36 6 Pak et al., 2020 [35 ] Prospective cohort study Korea RP Based on replication-competent adenovirus NR (0–48) 44/44 61/61 70/73 117/130 8
RP: radical prostatectomy; RT: radiotherapy; CTC: circulating tumor cell; CSS: Cell Search System; RT-PCR: reverse transcription-polymerase chain reaction; RBC: red blood cell; BF: biochemical recurrence; PSA: prostate-specific antigen; NR: not reported.