Whole Volume Apparent Diffusion Coefficient (ADC) Histogram as a Quantitative Imaging Biomarker to Differentiate Breast Lesions: Correlation with the Ki-67 Proliferation Index

Table 2

Comparison of different parameters of whole volumetric ADC histogram ROC curves in differentiation of benign and malignant breast lesions.

Parameter	Benign	Malignant	AUC	95% CI	Sensitivity	Specificity	Cut-off	value
10%	1.259	0.807	0.922	0.874~0.956	91.4	88.1	1.022	<0.001
50%	1.591	1.077	0.943	0.900~0.972	86.7	90.5	1.288	<0.001
90%	1.904	1.457	0.843	0.783~0.891	68.6	84.5	1.615	<0.001
Mean	1.585	1.106	0.930	0.884~0.962	87.6	85.7	1.331	<0.001
Skewness	-0.165	0.601	0.808	0.744~0.861	78.1	71.4	0.160	<0.001
Kurtosis	0.785	1.659	0.705	0.635~0.769	77.1	65.5	0.540	<0.001
Entropy	5.691	6.724	0.768	0.701~0.826	80.0	71.4	5.740	<0.001