Whole Volume Apparent Diffusion Coefficient (ADC) Histogram as a Quantitative Imaging Biomarker to Differentiate Breast Lesions: Correlation with the Ki-67 Proliferation Index

Table 4

Comparison of different parameters of whole volumetric ADC histogram ROC curves in differentiation of low or high Ki-67 of breast cancer.

Ki-67 status
Parameter	<14% ()	≥14% ()	AUC	95% CI	Sensitivity (%)	Specificity (%)	Cut-off	value
ADC-10%	0.809	0.803	0.509	0.409~0.608	88.60	28.60	0.643	0.889
ADC-50%	1.114	1.103	0.532	0.433~0.630	44.29	74.29	1.029	0.591
ADC-90%	1.496	1.471	0.599	0.499~0.693	71.43	45.71	1.422	0.089
Skewness	0.397	0.646	0.647	0.547~0.737	70.00	60.00	0.390	0.007
Kurtosis	1.183	1.620	0.573	0.473~0.669	40.00	80.00	1.730	0.211
Entropy	6.103	7.319	0.746	0.651~0.826	75.71	65.71	6.290	<0.001