Pharmacological Mechanism of Danggui-Sini Formula for Intervertebral Disc Degeneration: A Network Pharmacology Study

Table 2

Cluster information of the protein-protein interaction (PPI) network for common genes.

Cluster	Score	Nodes	Edges	Gene symbol
1	48.483	59	1406	IL10, MAPK1, NFKBIA, MAPK14, CXCL10, MMP1, CASP9, CASP8, STAT1, CD40LG, PLAU, RELA, CDKN1A, HIF1A, CCND1, MAPK3, BCL2L1, AR, STAT3, CASP3, KDR, VEGFA, ALB, TP53, SPP1, CXCL8, PPARG, JUN, EGFR, PTEN, ESR1, MYC, EGF, AKT1, SIRT1, ADIPOQ, MPO, CAT, IL1B, TNF, FOS, PTGS2, IL6, HMOX1, MMP2, SERPINE1, CCL2, IL2, IFNG, IL4, CRP, ICAM1, VCAM1, NOS3, MMP3, NOS2, SELE, MMP9, MAPK8
2	4.706	18	40	IGF2, SOD1, CXCL2, NFE2L2, IL1A, IRF1, HSPB1, CCNB1, CDK4, CDK2, RB1, CCNA2, NCF1, GSK3B, CAV1, GJA1, CTNNB1, RUNX2
3	3	3	3	PLAT, THBD, F3
4	3	3	3	NRI12, CYP3A4, CYP2B6
5	2.5	5	5	G6PD, HMGCR, FASN, ACHE, PON1

Core genes are shown in italic.