Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

Table 4

Changes in pericytes at different time points of cerebral ischemia-reperfusion in mouse.

Studies	Animals	Model	Ischemia time	Reperfusion time	Pericyte-related indicators
Nishimura A et al. 2016 [32]	Male, WT(FVB/N) mouse, 20-35 g	MCAO (laser-induced)	60 min	1 d, 4 d, 7 d	PDGFR-β expression was highest on the fourth day after cerebral ischemia.
Yemisci M et al. 2009 [7]	Male, Swiss albino mouse	MCAO (nylon suture)	2 h	6 h	After 2 h of ischemia and reperfusion for 6 h, the middle cerebral artery successfully reopened after 2 h of ischemia, and the pericytes remained constricted. Anti-α-SMA antibody-positive microvascular cells partially overlapped with NG-2 antibody positivity in the same cells.
Nakata M et al. 2017 [33]	Male, CB-17 mouse	MCAO (nylon suture)	15 min, 20 min, 30 min	3 d, 5 d, 7 d	PDGFR β+ pericytes in the nonlethal ischemic injury zone begin to express the NSC marker nestin at day 3 of ischemia. Some PDGFR β+ pericytes express the immature neuronal marker bicortin at day 7.
Tan QS et al. 2017 [34]	Male, C57BL/6 mouse, 18-25 g	MCAO (nylon suture)	60 min	1 h	The number of α-SMA marker-positive cells (i.e., pericytes) in the ischemic cortical area was significantly increased, and the morphology was irregular.
Jean LeBlanc N et al. 2018 [35]	Male, C57BL6/j mouse	MCAO (nylon suture)	45 min	1 d, 4 d	PDGFR β+ pericytes are highly segregated from brain endothelial cells and activated by the formation of several cellular protrusions into the brain parenchyma through branching-like structures.