Recurrent Superenhancer of the Oncogene POU5F1B in Colorectal Cancers

Figure 1

Comparison of the superenhancer profiles of HCT116 and sigmoid colon tissue: (a) heat map of the superenhancers; (b) Venn diagram of the superenhancers of HCT116 and sigmoid colon tissue; (c) the H3K27ac peak enrichment at the superenhancer of SORBS1 in the sigmoid colon tissue; (d) tissue distribution of the expression of SORBS1; (e) SORBS1 expression in the tumor/tissue of different cancers; (f) GO enrichment of the HCT116 superenhancer genes; (g) gene association module of the GO enrichments in (f); (h) the motifs of overrepresented TFs in the HCT116 H3K27ac superenhancer peaks; (i) JQ-1 inhibits HCT116 colony formation.

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