Recurrent Superenhancer of the Oncogene POU5F1B in Colorectal Cancers

Figure 3

POU5F1B superenhancer is recurrent in CRC. (a) POU5F1B expression is abruptly high in the tumors of colorectal cancers (READ and COAD); (b) POU5F1B in the tumor and normal tissues in CRC; (c) high expression of POU5F1B also occurs in the shallow deletion and diploid and copy number gain groups; (d) POU5F1B superenhancer is recurrent in human CRC samples; (e) JQ-1 inhibited POU5F1B expressions in human CRC-derived cell culture, which had positive POU5F1B superenhancers; (f) diagram showing that superenhancer activation of POU5F1B is recurrent in CRCs.

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