Authors Sample size Study design Length of follow-up Comparator Measure Key findings Strengths Limitations Hakim et al. [16 ] Prospective study design 10 years Age- and sex-matched controls from general population Incidence of diastolic hypertension over time 60% vs. 17% Age- and sex-matched control from the general population and from inpatient population Yasumura et al. [17 ] Prospective observational study design 18 months–16 years Matching not performed Hypertension recorded as an outcome 2.4% Moderate sample size No matched control groups Abomelha et al. [18 ] Prospective observational study 3, 6, and 12 months postdonation Matching not performed Hypertension recorded from notes 2.9% Moderate sample size No matched control groups Holscher et al. [19 ] National cohort study Up to 2 years postdonation Matching not performed Hypertension recorded from notes 3% of donors at 2 years; higher risk identified among men, older donors, and those with higher BMI Large sample size No matched control groups Sanchez Observational, longitudinal cohort study 6, 12, and 24 months and then every 3 years between 1963 and 2014 Matching performed against population study NHANES Predominantly Caucasian donors Thiel et al. [25 ] Prospective observational study 10-year follow-up Patients were not individually matched. A hypertension risk score was generated and compared to an expected value derived from the Framingham hypertension risk. Hypertension defined as Predicted risk of developing hypertension increasing by 3.64 ( Large sample size The rate of smoking and family history of hypertension were assumed variable. Bhowmik et al. [29 ] Prospective observational study 3-month follow-up Matching not performed Hypertension clearly defined using ambulatory blood pressure measurements No statistically significant increase in ABPM pre- vs. postnephrectomy The use of ABPM to demonstrate blood pressure changes Small sample size Holscher et al. [28 ] Observational case-control study 6-year follow-up Matching was made against healthy nondonors drawn from large coexisting trials and weighted for age, race, and sex. Hypertension was defined as a self-reported outcome. Hazard ratio of developing Large cohort study Relied on self-reporting Saran et al. [32 ] Observational study 10-year follow-up The prevalence of hypertension was compared to data drawn from the Whickham and NHANES III population studies. Hypertension was defined as In the over 55 age group, the prevalence of hypertension was greater than the expected value from NHANES III and Whickham Hypertension clearly defined Population studies used rather than matching Gossmann et al. [33 ] Case-control observational study Assessed individual cases at a time point postdonation up to 28 years Compared cases to data drawn from a large German cohort study Blood pressure was compared as a variable rather than a hypertensive diagnosis. Prevalence of hypertension significantly lower among donors than nondonors ( Case-control design Mjøen et al. [45 ] Case-control study Assessed cardiovascular death and risk of end-stage renal disease in kidney donors vs. control Population data from the HUNT1 survey of Norway was used. Patients excluded based on health and age criteria. Robust matching to donor cohort Risk of death from cardiovascular or all-cause assessment Large study
