Research Article
Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice
| Sex | Group/dose (mg/kg) | Day | 1 | 4 | 8 | 15 |
| Male | G1/0 | Mean | 30.3 | 30.8 | 31.5 | 33.5 | SD | 0.7 | 0.7 | 0.9 | 1.6 | | 5 | 5 | 5 | 5 | G2/0 | Mean | 0.2 | 30.1 | 31.6 | 33.4 | SD | 1.2 | 2.1 | 1.8 | 1.8 | | 5 | 5 | 5 | 5 | G3/125 | Mean | 30.5 | 30.5 | 31.4 | 33.6 | SD | 1.7 | 1.7 | 1.8 | 1.9 | | 5 | 5 | 5 | 5 | G4/250 | Mean | 30.4 | 30.2 | 31.5 | 33.4 | SD | 1.2 | 1.4 | 1 | 2.2 | | 5 | 5 | 5 | 5 | G5/500 | Mean | 30.4 | 30.8 | 33.0 | 35.4 | SD | 1.4 | 0.2 | 1.5 | 0.6 | | 5 | 2 | 2 | 2 |
| Female | G1/0 | Mean | 22.8 | 22.9 | 24.3 | 26.3 | SD | 1.8 | 1.3 | 2.1 | 1.1 | | 5 | 5 | 5 | 5 | G2/0 | Mean | 22.9 | 22.0 | 23.8 | 25.8 | SD | 0.9 | 0.3 | 1.0 | 1.7 | | 5 | 5 | 5 | 5 | G3/125 | Mean | 22.6 | 23.3 | 24.6 | 26.9 | SD | 1.5 | 1.4 | 1.9 | 1.7 | | 5 | 5 | 5 | 5 | G4/250 | Mean | 22.6 | 22.4 | 24.2 | 25.5 | SD | 1.4 | 1.1 | 1.0 | 1.2 | | 5 | 5 | 5 | 5 | G5/500 | Mean | 22.9 | 22.4 | 24.7 | 26.2 | SD | 1.4 | 2.2 | 1.0 | 1.6 | N | 5 | 4 | 4 | 4 |
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G1: negative control; G2: vehicle control. Data represent the , and no significant difference was found in one-way analysis of variance ( ). |