Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice

Table 3

Incidence of macroscopic findings in the liver.

(a)

Organ/findings	Sex	Male
	Group/dose (mg/kg)	G1/0	G2/0	G3/125	G4/250	G5/500
		Negative control	Vehicle control	Low dose	Mid dose	High dose
Number examined		5	5	5	5	2
Liver
Thickening, lobar edge, all lobes		0	0	0	5	2
Total number of affected animals		^#0/5	0/5	0/5	5/5	2/2
Adhesion, to adjacent organs/tissues (stomach, diaphragm)		0	0	0	5	2
Total number of affected animals		^#0/5	0/5	0/5	5/5	2/2

(b)

Organ/findings	Sex	Female
	Group/dose (mg/kg)	G1/0	G2/0	G3/125	G4/250	G5/500
		Negative control	Vehicle control	Low dose	Mid dose	High dose
Number examined		5	5	5	5	4
Liver
Thickening, lobar edge, all lobes		0	0	0	5	4
Total number of affected animals		^#0/5	0/5	0/5	5/5	4/5
Adhesion, to adjacent organs/tissues (stomach, diaphragm)		0	0	0	5	4
Total number of affected animals		^#0/5	0/5	0/5	5/5	4/5

Number of affected mice on liver. ^#Number of with affected mice/total mice. Data was no significant difference after using the chi-square test (all ).