Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice

Table 4

Incidence and severity of microscopic findings in the liver.

Tissue/findings	Sex	Male		Female
	Group/dose (mg/kg)	G4/250	G5/500	G4/250	G5/500
		Mid dose	High dose	Mid dose	High dose
Number examined		5	2	5	4
Liver
Fibrosis, capsular, with inflammatory cell infiltrate
Minimal		5	2	5	4
Total number of affected animals		^#5/5	2/2	5/5	4/4
Increased mitosis, hepatocyte
Minimal		2	2	1	3
Total number of affected animals		^#2/5	2	1	3
Hypertrophy, hepatocyte, centrilobular
Minimal		2	0	1	1
Slight		1	2	0	1
Total number of affected animals		^#3/5	2/2	1/5	2/4

Number of affected mice on the liver. ^#Number of with affected mice/total mice. Data was no significant difference after using the chi-square test (all ).