Research Article
In Silico Drug Screening Analysis against the Overexpression of PGAM1 Gene in Different Cancer Treatments
Table 2
ADMET profiling, absorption, metabolism, and toxicity-related drug-like parameters of candidate compounds.
| A. ADMET profiling | Compounds | N-Nitrosohexamethyleneimine | Subtrifloralactone-K | Kanzonol-N |
| A. Absorption | Blood-brain barrier | — | + | — | Human intestinal absorption | — | + | + | P-glycoprotein substrate | + | + | — | B. Metabolism | CYP450 1A2 inhibitor | — | — | + | CYP450 2C9 inhibitor | — | — | + | CYP450 2D6 inhibitor | — | — | — | CYP450 2C19 inhibitor | — | — | + | CYP450 3A4 inhibitor | — | — | — | Distribution | Subcellular localization | Lysosomes | Mitochondria | Mitochondria | Toxicity | AMES toxicity | No | No | No |
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