Text Mining and Hub Gene Network Analysis of Endometriosis

Figure 4

Text mining and hub gene analysis of three subtypes of endometriosis. (a) Bar plot of the number of the publications retrieved from PubMed by using “peritoneal endometriosis,” “ovarian endometriosis,” and “deep infiltrating endometriosis” as search terms. The publication date was set as from January 1, 1970, to January 1, 2020, in search input for PubMed. (b) Bar plot of the numbers of the genes appeared in the abstract of retrieved publications for each endometriosis subtype. The red bar represents the total genes that appeared in the endometriosis subtype-associated publications, while the blue bar represents the genes that were significantly cocited with the endometriosis subtype. False discovery adjusted binomial test was used to determine the significance of the gene being cocited with each subtype. (c) Venn diagram showing the common or endometriosis subtype-specific hub genes. Each circle represents one endometriosis subtype. The number in each area represents the number of hub genes which were shown in each intersect. PE: peritoneal endometriosis; OE: ovarian endometriosis; DIE: deep infiltrating endometriosis.

(a)

(b)

(c)