A Network Pharmacology and Molecular Docking Strategy to Explore Potential Targets and Mechanisms Underlying the Effect of Curcumin on Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus

Table 1

Topological analysis of curcumin target network.

Name	ASPL	BC	CC	Clustering coefficient	Degree
TP53	2.015625	0.11128227	0.49612403	0.20244898	50
SRC	2.05729167	0.1213118	0.48607595	0.18454106	46
STAT3	2	0.08600855	0.5	0.23809524	43
AKT1	2.078125	0.08456637	0.48120301	0.20557491	42
MAPK3	2.06770833	0.0426935	0.4836272	0.26666667	40
MAPK1	2.05208333	0.07932813	0.48730964	0.25	40
EP300	2.125	0.09219908	0.47058824	0.20769231	40
JUN	2.0625	0.05135675	0.48484848	0.28609987	39
RELA	2.16666667	0.03133128	0.46153846	0.3125	32
VEGFA	2.11979167	0.04222026	0.47174447	0.27513228	28
TNF	2.25	0.03547444	0.44444444	0.29365079	28
FOS	2.1875	0.02564237	0.45714286	0.33903134	27
HSP90AA1	2.13541667	0.04893392	0.46829268	0.2991453	27
MAPK14	2.18229167	0.02577391	0.45823389	0.31054131	27
MYC	2.27604167	0.01608063	0.43935927	0.38666667	25
RB1	2.29166667	0.02207007	0.43636364	0.4	25
CCND1	2.27604167	0.01473079	0.43935927	0.40333333	25
EGFR	2.22916667	0.03631959	0.44859813	0.30434783	24
CDKN1A	2.34375	0.01530251	0.42666667	0.46014493	24
CDK1	2.53645833	0.01897448	0.39425051	0.43478261	23
ESR1	2.19270833	0.05987742	0.45605701	0.37944664	23
JAK2	2.40625	0.01035399	0.41558442	0.29437229	22
IL6	2.40625	0.0188487	0.41558442	0.37662338	22
CASP3	2.44791667	0.03709723	0.40851064	0.1991342	22
CXCL8	2.36458333	0.03987748	0.42290749	0.33766234	22
CASP8	2.40625	0.02257322	0.41558442	0.28095238	21
MMP9	2.48958333	0.0374213	0.40167364	0.29473684	20
CCNA2	2.77083333	0.00477339	0.36090226	0.47894737	20
CDK2	2.57291667	0.00859466	0.38866397	0.52105263	20
PTK2	2.328125	0.0222	0.4295302	0.26315789	19