Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients

Figure 5

Identification of differentially expressed genes between RA and OA in GSE56409. (a) Heatmap of differential gene expression in RA and OA. RA: rheumatoid arthritis; OA: osteoarthritis. Red are upregulation and blue are downregulation. (b) Volcano plot of differentially expressed genes between RA and OA. Red are upregulation and blue are downregulation. (c) PPI network of differentially expressed genes. The colors from blue to red, representing the greater degree to which genes are connected in the network. (d) Venn diagram of the intersection among cluster 0, cluster 3, and the top 20 degrees in the PPI network. Then obtained eight key genes. (e) Differential expression of key genes between RA and OA in GSE56409. RA: rheumatoid arthritis; OA: osteoarthritis. (f) ROC curve of key genes for predicting diagnosis of RA. AUC: area under ROC curve.

(a)

(b)

(c)

(d)

(e)

(f)