Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients

Figure 6

Changes of immune cell and key genes in RA patients. (a) Infiltration levels of immune cells in RA and OA. RA: rheumatoid arthritis; OA: osteoarthritis. Red represents high infiltration and blue represents low infiltration. (b) The difference of infiltration for immune cells in RA compared to OA. RA: rheumatoid arthritis; OA: osteoarthritis. (c) Correlations between immune cells and key genes were analyzed through Pearson correlation. Node color from blue to red represents negative to positive correlation. . (d) The levels of CD8+T cell, neutrophils, and B cell in blood samples of RA and OA patients were detected by flow cytometry. (e) QRT-PCR was used to detect the mRNA levels of key genes in synovial tissue of RA and OA patients. , . (f) Western blot was used to detect the expression of key genes in synovial tissue of RA and OA patients.

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