Structural and Evolutionary Adaptation of NOD-Like Receptors in Birds

Figure 1

Adaptive substitutions in avian NLRs NACHT domain. We have aligned the NACHT domain of NLRs (human and Gallus shown). Adaptive amino acid substitutions and important motif of NACHT are indicated along the top of the alignment. Adaptive amino acid substitutions in NACHT are represented with star (); motifs involved in ATP binding and hydrolysis of NACHT are indicated along the top of the alignment.