Structural and Evolutionary Adaptation of NOD-Like Receptors in Birds

Figure 5

WebLogo of the putative TRAF2-binding sites constructed from alignment of 41 birds NLRC3 sequences. The residue numbering corresponds to the residues from chicken NLRC3. TRAF-binding motif mainly contains four residues with (P/S/A/T)-X-(Q/E)-E in the NACHT domain; “P/S/A/T” represents Pro, Ser, Ala, or Thr; “X” indicates any amino acid; “Q/E” represents Gln or Glu. Major TRAF2-binding motifs in birds NLRC3 are at the region of 483-486 and 608-611. The letter size is proportional to the degree of amino acid conservation. The weblogo was made using the web-based application WebLogo (http://weblogo.berkeley.edu).