Beneficial Effect of Statin Therapy on Arterial Stiffness

Figure 1

Suggested statin mechanisms of action to improve arterial elasticity. mRNA, RNA messenger; NO, nitric oxide; eNOS, endothelial NO synthase; ET-1, endothelin 1; ROCK, Rho-associated protein kinase; AT-1, angiotensin II receptor type 1; PI3k, phosphoinositide 3-kinase; Akt, protein kinase B; CRP, C-reactive protein; BH4, tetrahydrobiopterin; GTP, guanosine triphosphate.