The Relationship of Large-Artery Atherothrombotic Stroke with Plasma Trimethylamine N-Oxide Level and Blood Lipid-Related Indices: A Cross-Sectional Comparative Study

Table 2

Odds ratios and areas under the curve for stroke risk per one sex-specific standard deviation increase of parameters.

Parameters	Unadjusted model			Adjusted model^1
	OR (95% CI)	value	AUC (95% CI)	OR (95% CI)	value	AUC (95% CI)
TMAO (ng/mL)	3.99 (2.16, 7.36)	<0.01	0.79 (0.70, 0.88)	7.03 (2.86, 17.25)	<0.01	0.89 (0.83, 0.95)
Area of carotid artery plaque (mm^2)	1.07 (0.72, 1.59)	0.74	0.52 (0.40, 0.63)	1.00 (0.63, 1.59)	0.99	0.78 (0.69, 0.88)
Apo-A1 (g/L)	0.53 (0.34, 0.83)	0.01	0.67 (0.57, 0.78)	0.56 (0.34, 0.91)	0.02	0.81 (0.72, 0.89)
Apo-B (g/L)	1.43 (0.95, 2.17)	0.09	0.61 (0.50, 0.72)	1.74 (1.06, 2.85)	0.03	0.81 (0.73, 0.90)
Apo-A1 to Apo-B ratio	0.30 (0.17, 0.53)	<0.01	0.75 (0.66, 0.85)	0.29 (0.15, 0.56)	<0.01	0.85 (0.78, 0.93)
TC (mmol/L)	0.72 (0.54, 0.96)	0.02	0.65 (0.54, 0.76)	1.32 (0.83, 2.10)	0.24	0.79 (0.70, 0.88)
HDL-C (mmol/L)	0.61 (0.40, 0.93)	0.02	0.64 (0.54, 0.75)	0.56 (0.35, 0.91)	0.02	0.81 (0.72, 0.89)
LDL-C (mmol/L)	0.80 (0.56, 1.15)	0.23	0.59 (0.48, 0.70)	1.21 (0.77, 1.89)	0.41	0.78 (0.69, 0.88)
TG (mmol/L)	0.89 (0.62, 1.28)	0.52	0.55 (0.43, 0.66)	1.50 (0.91, 2.47)	0.11	0.80 (0.71, 0.89)

Abbreviations: OR: odds ratio; CI: confidence interval; AUC: area under the curve; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglycerides. ¹Adjusted for age and gender.