Review Article
The Accuracy of 16S rRNA Polymerase Chain Reaction for the Diagnosis of Neonatal Sepsis: A Meta-Analysis
Table 2
Summary estimates of the diagnostic performance of 16S rRNA PCR in neonatal sepsis diagnosis.
| | Analysis | Number of studies | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC (95% CI) |
| | Overall | 1912, 13, 25-41 | 0.98 (0.85-1.00) | 0.94 (0.87-0.97) | 16.0 (7.6-33.9) | 0.02 (0.00-0.18) | 674 (89-5100) | 0.99 (0.97-0.99) | | Influence studies excluded | 1613, 25-28, 30-36, 38-41 | 0.99 (0.84-1.00) | 0.95 (0.92-0.97) | 19.5 (12.9-29.4) | 0.01 (0.00-0.20) | 1464 (103-20881) | 0.98 (0.96-0.99) | | Outlier excluded | 1813, 25-41 | 0.97 (0.83-1.00) | 0.95 (0.91-0.97) | 19.2 (10.6-34.7) | 0.03 (0.00-0.20) | 612 (87-4290) | 0.98 (0.97-0.99) |
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