Bortezomib Inhibits Hypoxia-Induced Proliferation by Suppressing Caveolin-1/SOCE/[Ca<sup>2+</sup>]<sub>i</sub> Signaling Axis in Human PASMCs

<div>Effects of short-term treatments of bortezomib (BTZ) or chloroquine (CHQ) on Caveolin-1 protein expression in normoxic and hypoxic (4% O<sub>2</sub>) human pulmonary arterial smooth muscle cells (PASMCs). Western blots (a) and bar graph (b) representing the protein expression level of Caveolin-1, p21, and LC3B upon treatment with BTZ (10 nM) or CHQ (<i>μ</i>M) for 3, 6, and 12 hours in human PASMCs under normoxic and hypoxic conditions. Beta tubulin was used as house-keeping protein. 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BioMed Research International

fig1

Figure 1

Figure 1: Bortezomib Inhibits Hypoxia-Induced Proliferation by Suppressing Caveolin-1/SOCE/[Ca<sup>2+</sup>]<sub>i</sub> Signaling Axis in Human PASMCs 

BioMed Research International

Bortezomib Inhibits Hypoxia-Induced Proliferation by Suppressing Caveolin-1/SOCE/[Ca2+]i Signaling Axis in Human PASMCs

Figure 1

Bortezomib Inhibits Hypoxia-Induced Proliferation by Suppressing Caveolin-1/SOCE/[Ca²⁺]_i Signaling Axis in Human PASMCs