BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy

<div>Cell viability of Huh7 and Huh7<sup>R</sup> cells and the effect of SFB on apoptosis in Huh7 and Huh7<sup>R</sup> cells. (a and b) The inhibitory effect (IC<sub>50</sub>) of sorafenib or BEZ235 on Huh7 and Huh7<sup>R</sup> at various concentrations for 24 or 48 h. (c) The inhibition rate of proliferation in each group at various concentrations of sorafenib. (d) The effect of sorafenib, BEZ235, or sorafenib combined with BEZ235 on cell proliferation at 12, 24, and 48 h (SFB, 4 <i>μ</i>M; BEZ235, 0.25 <i>μ</i>M; SFB 4 <i>μ</i>M + BEZ 0.25 <i>μ</i>M). (e) The effect of sorafenib on apoptosis in Huh7 and Huh7<sup>R</sup> cells. 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SFB: sorafenib; BEZ: BEZ235; SFB + BEZ: sorafenib combined with BEZ235.</div>

BioMed Research International

fig1

Figure 1

Figure 1: BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy 