Molecular Docking and Simulation Studies of Antidiabetic Agents Devised from Hypoglycemic Polypeptide-P of Momordica charantia

Figure 1

Docking of KDDGHL peptide with insulin receptor. (a) Interactions of peptide with IR. In these interactions, His1058 is a basic amino acid and acting as a sidechain donor. Glu1108, Glu1115, and Asp1143 are acidic amino acids and acting as sidechain acceptors. (b) Binding pattern of KDDGHL with the binding pocket of IR.

(a)

(b)