Molecular Docking and Simulation Studies of Antidiabetic Agents Devised from Hypoglycemic Polypeptide-P of Momordica charantia

Figure 2

Docking of ESIRD peptide with SGLT1 receptor. (a) Interactions of peptide with SGLT1. In these interactions, Ser66, Gln69, Ser364, Ser368, Gln428, and Thr431 are polar amino acids and acting as sidechain acceptors. Asn142 is also a polar amino acid but acting as a sidechain donor. Lys294 and Glu88 are basic and acidic amino acids and acting as sidechain donor and acceptor, respectively. (b) Binding pattern of ESIRD with the binding pocket of SGLT1.

(a)

(b)