Molecular Docking and Simulation Studies of Antidiabetic Agents Devised from Hypoglycemic Polypeptide-P of Momordica charantia

Figure 3

Docking of LIVA peptide with insulin receptor. (a) Interactions of LIVA with IR. In these interactions, GlnA1004 and SerA1006 are polar amino acids and acting as backbone acceptor and backbone donor, respectively. AsnA1137 is a polar amino acid and acting as a sidechain acceptor. The amino acid AspA1150 is acidic in nature and acting as backbone acceptor while MetA1153 (greasy in nature) is acting as backbone donor. (b) Binding pattern of LIVA with the binding pocket of IR.

(a)

(b)