Research Article
Molecular Docking and Simulation Studies of Antidiabetic Agents Devised from Hypoglycemic Polypeptide-P of Momordica charantia
Table 5
ADMET profiling enlisting absorption, metabolism, and toxicity-related drug-like parameters of best selected peptides.
| | Peptides | LIVA | TSEP | EKAI | LKHA | EALF | VAEK | DFGAS | EPGGGG |
| Absorption | BBB | + | + | + | + | – | + | + | + | HIA | – | – | – | + | + | – | – | + | Caco-2 permeability | Caco-2- | Caco-2- | Caco-2- | Caco-2- | Caco-2- | Caco-2- | Caco-2- | Caco-2- | PGS | Substrate | NS | Substrate | Substrate | Substrate | NS | NS | Substrate | PGI | NI | NI | NI | NI | NI | NI | NI | NI | ROCT | NI | NI | NI | NI | NI | NI | NI | NI |
| Metabolism | CYP3A4 substrate | Substrate | NS | Substrate | Substrate | NS | NS | NS | Substrate | CYP2C9 substrate | NS | NS | Substrate | NS | NS | NS | NS | Substrate | CYP2D6 substrate | NS | NS | NS | NS | NS | NS | NS | NS | CYP3A4 inhibition | NI | NI | NI | NI | NI | NI | NI | NI | CYP2C9 inhibition | NI | NI | NI | NI | NI | NI | NI | NI | CYP2C19 inhibition | NI | NI | NI | NI | NI | NI | NI | NI | CYP2D6 inhibition | NI | NI | NI | NI | NI | NI | NI | NI | CYP1A2 inhibition | NI | NI | NI | NI | NI | NI | NI | NI |
| Toxicity | Ames toxicity | NAT | NAT | NAT | NAT | NAT | NAT | NAT | NAT | Carcinogens | NC | NC | NC | NC | NC | NC | NC | NC |
|
|
BBB: blood-brain barrier; HIA: human intestinal absorption; PGS: P-glycoprotein substrate; PGI: P-glycoprotein inhibitor; ROCT: renal organic cation transporter; NS: nonsubstrate; NI: noninhibitor; NAT: non-Ames toxic; NC: noncarcinogenic.
|