Screening and Identifying m6A Regulators as an Independent Prognostic Biomarker in Pancreatic Cancer Based on The Cancer Genome Atlas Database

Table 5

Univariate and multivariate COX regression analyses of m6A regulatory genes for PAAD patients’ overall survival (OS) and disease-free survival (DFS).

	OS				DFS
Variable	Univariate		Multivariate		Univariate	Multivariate	Univariate	Multivariate
	HR (95% CI)		HR		HR (95% CI)		HR
Age (>60 vs. ≤60)	1.383 (0.883-20165)	0.156	1.387 (0.854-2.253)	0.187	0.976 (0.622-1.533)	0.917	0.733 (0.446-1.205)	0.221
Gender (male vs. female)	1.192 (0.793-1.792)	0.398	1.561 (0.962-2.533)	0.071	1.137 (0.732-1.767)	0.568	1.506 (0.887-2.556)	0.129
Stage (I-II vs. III-IV)	1.165 (0.835-1.624)	0.369	1.168 (0.574-2.376)	0.669	2.120 (1.111-4.047)	0.023	1.162 (0.576-2.346)	0.675
M (M1 vs. M0)	1.050 (0.251-4.388)	0.947			0.936 (0.226-3.885)	0.928
N (N1 vs. N0)	2.151 (1.281-3.612)	0.004	2.119 (1.184-3.793)	0.011	1.750 (1.065-2.875)	0.027	1.488 (0.844-2.623)	0.169
T (T3-T4 vs. T1-T2)	0.92 (0.250-2.513)	0.693	0.878 (0.258-2.987)	0.835	1.078 (0.339-3.431)	0.898	1.455 (0.419-5.056)	0.555
Grade (3-5 vs. 1-2)	1.496 (0.970-2.308)	0.069	1.146 (0.709-1.854)	0.578	1.740 (1.094-2.767)	0.019	1.424 (0.854-2.375)	0.175
KRAS (altered vs. diploid)	1.170 (0.75-1.825)	0.490	1.836 (1.058-3.185)	0.031	0.890 (0.547-1.449)	0.640	1.673 (0.869-3.219)	0.123
TP53 (altered vs. diploid)	1.242 (0.817-1.889)	0.311	1.140 (0.672-1.932)	0.628	0.986 (0.634-1.533)	0.950	0.986 (0.561-1.732)	0.961
SMAD4 (altered vs. diploid)	1.234 (0.766-1.987)	0.387	1.066 (0.590-1.926)	0.831	1.653 (0.976-2.800)	0.062	1.095 (0.568-2.110)	0.786
CDKN2A (altered vs. diploid)	1.307 (0.837-2.042)	0.238	0.950 (0.667-1.352)	0.774	1.480 (0.929-2.356)	0.099	0.915 (0.619-1.353)	0.657
WTAP (write loss vs. others)	1.325 (0.879-1.998)	0.179	1.291 (0.799-2.085)	0.298	1.245 (0.802-1.932)	0.329	1.255 (0.729-2.162)	0.412
Mettl3 (write loss vs. others)	0.918 (0.488-1.725)	0.790	0.648 (0.308-1.364)	0.253	1.269 (0.670-2.403)	0.464	0.869 (0.405-1.867)	0.720
Mettl14 (write loss vs. others)	1.199 (0.707-2.034)	0.501	1.378 (0.747-2.543)	0.305	1.639 (0.956-2.812)	0.073	1.970 (1.037-3.741)	0.038
FTO (eraser gain vs. others)	1.236 (0.684-2.234)	0.483	0.968 (0.483-1.942)	0.928	1.490 (0.799-2.778)	0.209	1.062 (0.499-2.263)	0.875
ALKBH5 (eraser gain vs. others)	0.229 (0.072-0.731)	0.013	0.287 (0.083-0.988)	0.048	0.199 (0.062-0.641)	0.007	0.201 (0.053-0.763)	0.018

Ambiguous variables (Nx, Mx, N/A, discrepancy, and Gx) were excluded. value < 0.005.