A Missense <i>POU4F3</i> Variant Associated with Autosomal Dominant Midfrequency Hearing Loss Alters Subnuclear Localization and Transcriptional Capabilities

<div>Representative fluoroscopy images depicting subcellular localization of wild-type (WT) and mutant (MUT) POU4F3. Transient expression of WT and MUT POU4F3 in HeLa cells showing nuclear localization of both WT and MUT POU4F3. Compared to WT POU4F3, the MUT POU4F3 exhibited a region-specific localization within the nucleus. GFP: green fluorescent protein; DIC: differential interference contrast microscope.</div>

BioMed Research International

fig2

Figure 2

Figure 2: A Missense <i>POU4F3</i> Variant Associated with Autosomal Dominant Midfrequency Hearing Loss Alters Subnuclear Localization and Transcriptional Capabilities 

Figure 2 | A Missense POU4F3 Variant Associated with Autosomal Dominant Midfrequency Hearing Loss Alters Subnuclear Localization and Transcriptional Capabilities 