Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro

Figure 5

CED treatment activated autophagy in A549 cells. (a) A549 cells from indicated treatment groups were incubated for 48 h, and autophagy relative proteins (LC3B and Beclin1) were detected using western blot. (b) Quantitative analysis of Beclin1, LC3-I, and LC3-II proteins in A549 cells by western blot analysis. (c) The localization of LC3B protein in A549 cells supplemented with CED was determined by fluorescent microscopy. All data are representative of three independent experiments. The data are expressed as the . (vs. control group).

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