Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro

Figure 7

Schematic depicting the effect of CED on cell survival and the underlying mechanism. CED inhibits the expression of VEGFR2/3 and suppresses MAPK/Erk1/2 and Akt/mTOR signaling pathways in A549 cells. This eventually leads to apoptosis, G1 phase cell cycle arrest, and autophagy, as featured by the decrease of G1 phase relative proteins CDK4/cyclin D1 and CDK2/cyclin E and the increase of autophagy relative proteins LC3-II and Beclin1.