[Retracted] Identification of Hearing Loss-Associated Variants of PTPRQ, MYO15A, and SERPINB6 in Pakistani Families

Figure 2

Protein structure, molecular modeling, and Ramachandran plots. (a) Schematic representations of PTPRQ, SERPINB6, and MYO15A proteins along with HL-causing variants were identified in Pakistani families. (b) 3-dimentional molecular modeling of SERPINB6. Protein secondary structures generated by Phyre2 are shown in respective colors: helix, cyan; strand, purple; and coils, green. The protein surface is displayed in a meshwork. Concerned residue is shown in firebrick color, while the aberrant hydrogen bonding due to p.Arg360Gln variant is displayed in golden yellow color. (c) Ramachandran plots of both wild and mutant protein PDB structures; the wild structure shows 88% of the residues existing in the favored region, and 96% of the residues are located in the allowed region, but 68% of the residues in mutant structure are found in the favored region and 86% are in the allowed region, respectively.

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