Increase in Free Hepatic Venous Pressure Response to Beta-Blockers Predicts Variceal Bleeding in Cirrhotic Patients

Table 4

Univariate and multivariate analyses for factors associated with variceal bleeding.

	Univariate analysis		Multivariate analysis
Variable	Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age	0.994 (0.957-1.031)	0.734
Gender (male vs. female)	0.963 (0.404-2.295)	0.932
CTP^1 grade
A	Reference
B	0.842 (0.352-2.011)	0.698
Ascites
No	Reference
Mild	2693.596 (0-4.810+103)	0.947
Moderate	3194.624 (0-5.704+103)	0.945
Massive	3547.758 (0-6.337+103)	0.945
TBil^2	1.012 (0.983-1.043)	0.417
FHVP^3 group
FHVP decreased or unchanged	Reference		Reference
FHVP increased	2.692 (1.123-6.457)	0.026	2.692 (1.123-6.457)	0.026
Hemodynamic response group
Responders	Reference
Nonresponders	0.733 (0.283-1.900)	0.523
Baseline HVPG^4	1.071 (0.927-1.238)	0.353

¹CTP: Child-Turcotte-Pugh; ²TBil: total bilirubin; ³FHVP: free hepatic vein pressure; ⁴HVPG: hepatic venous pressure gradient.