Mitophagy Impairment Aggravates Cisplatin-Induced Ototoxicity

<div>Cisplatin reduces the HEI-OC1 cell viability and upregulates mitophagy-associated proteins. HEI-OC1 cells were treated with 10 <i>μ</i>M cisplatin for 0 (control), 8, 16, and 24 h. (a) Cell survival decreasing with cisplatin exposure in a time-dependent manner. (b, c) Cisplatin exposure increasing the expression of mitophagy-associated proteins. (b) Representative immunoblots of <i>PINK1</i>, <i>Parkin</i>, <i>BNIP3</i>, <i>FUNDC1</i>, p62, LC3B, and COX IV (loading control) from cell lysates harvested after the indicated cisplatin treatment time. (c) Mean changes in the expression of <i>PINK1</i>, <i>Parkin</i>, <i>BNIP3</i>, <i>FUNDC1</i>, p62, and LC3B relative to that of COX IV using densitometry analyses. 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BioMed Research International

Mitophagy Impairment Aggravates Cisplatin-Induced Ototoxicity

Figure 1