WGCNA-Based Identification of Hub Genes and Key Pathways Involved in Nonalcoholic Fatty Liver Disease

Figure 2

Construction of coexpression modules. (a) The 57 samples of GSE126848 were clustered at the expression level. The samples had 3 traits: nonalcoholic fatty liver diseases (NAFLD), including NAFL (pink) and NASH (red) disease states, obese, and normal. (b) Analysis of the scale-free fit index for various soft-thresholding powers (β) and analysis of the mean connectivity for various soft-thresholding powers, and 9 was the most fit power value. (c) The cluster dendrogram of module eigengenes. (d) The cluster dendrogram of genes in GSE126848. Each color represented a module, and the grey color represented genes not included in any module. After the merger, 28 modules were obtained. (e) Heatmap of the correlation between module eigengenes and the disease status of NAFLD. The steelblue module was the most positively correlated with status, and the brown module was the most negatively correlated with status.

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