Proanthocyanidins as a Potential Novel Way for the Treatment of Hemangioma

Table 2

Structure, distribution, and characteristics of proanthocyanidins.

Structure	Distributions	Functions	Metabolism	Application	Side effects
	Fruit/seeds/peel (grapes, apples, blackcurrants, etc.)	Antiangiogenesis	Broken down into monomers in the intestine	Cardiovascular disease	No obvious side effects, even in pregnant women
oligomeric proanthocyanidins	Leaves	Antiproliferation	Widely bound in the liver	Neurodegenerative disorder
polymeric proanthocyanidins	Flower	Antioxidation	Excreted by the kidneys	Metabolic disease
	Root/stem	Anti-inflammation		Osteoarthritis
		Antitumor		Cancer