Antitumor Effect of Saikosaponin A on Human Neuroblastoma Cells

Figure 7

The effect of SSA on human non-MYCN NB cells. SSA could inhibit NB cells’ angiogenesis by inhibiting the VEGFR/Src/Akt pathway. SSA could induce NB cells apoptosis via the Bax/cytochrome C/C9/C7/PARP pathway by inhibiting Bcl-2. SSA could inhibit EMT by inhibiting the mesenchymal markers and inducing the epithelial markers.