Bioinformatic Analysis of Key Genes and Pathways Related to Keloids

Table 1

Enriched terms for upregulated and downregulated networks detected by MCODE.

Enriched terms for upregulated network detected by MCODE
MCODE_1	GO:0007200	Phospholipase C-activatingG protein-coupled receptor signaling pathway	R-HSA-416476	G alpha (q) signaling events	R-HSA-373076	Class A/1 (rhodopsin-like receptors)
MCODE_2	R-HSA-1650814	Collagen biosynthesis and modifying enzymes	R-HSA-1474290	Collagen formation	R-HSA-1474244	Extracellular matrix organization
MCODE_3	R-HSA-1566948	Elastic fiber formation	R-HSA-1474244	Extracellular matrix organization	GO:0030198	Extracellular matrix organization
MCODE_4	GO:0071902	Positive regulation of protein serine/threonine kinase activity	GO:0018108	Peptidyl-tyrosine phosphorylation	GO:0018212	Peptidyl-tyrosine modification
MCODE_5	R-HSA-2022870	Chondroitin sulfate biosynthesis	GO:0030206	Chondroitin sulfate biosynthetic process	GO:0050650	Chondroitin sulfate proteoglycan biosynthetic process
Enriched terms for downregulated network detected by MCODE
MCODE_1	GO:0090131	Mesenchyme migration	GO:0014866	Skeletal myofibril assembly	R-HSA-397014	Muscle contraction
MCODE_2	R-HSA-373076	Class A/1 (rhodopsin-like receptors)	R-HSA-418594	G alpha (i) signaling events	R-HSA-500792	GPCR ligand binding
MCODE_3	GO:0070268	Cornification	R-HSA-6809371	Formation of the cornified envelope	R-HSA-6805567	Keratinization