Characterization and Pharmacokinetic Evaluation of Oxaliplatin Long-Circulating Liposomes

Table 8

Pharmacokinetic parameters of total platinum in plasma after intravenous injection of L-OHP, L-OHP bare lip, and L-OHP PEG lip to rats (10 mg/kg, ).

Parameters	L-OHP	L-OHP bare lip	L-OHP PEG-lip
(μg/mL)
(h)
(h)
(μg.h/mL)
CL (L/h/kg)

: initial plasma concentration; : half-life in the phase; : half-life in the phase; : area under the curve (from 0 to infinity); MRT: mean residence time; CL: clearance; statistically significant difference compared with L-OHP group (, , and ).