Cilengitide Inhibits Neovascularization in a Rabbit Abdominal Aortic Plaque Model by Impairing the VEGF Signaling

<div>Schematic illustration of the effect of cilengitide on the HUVECs. Recognizing the ligands with conserved arginine-glycine-aspartic acid (RGD) motifs, integrin <i>α</i><sub>v</sub><i>β</i><sub>3</sub> mediates the various activities of cell adhesion. Cilengitide has a high affinity for integrin <i>α</i><sub>v</sub><i>β</i><sub>3</sub> and inhibits relevant intracellular signaling. It inhibits the proliferation, migration, and tube formation of HUVECs but not affects apoptosis.</div>

BioMed Research International

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Figure 11

Figure 11: Cilengitide Inhibits Neovascularization in a Rabbit Abdominal Aortic Plaque Model by Impairing the VEGF Signaling 